Raine Priming Grants 1999-2010


Professor YC Gary Lee

School of Medicine and Pharmacology
Antagonizing transforming growth factor-ß activity in the management of pleural infection

Associate Professor Neil Boudville

School of Medicine and Pharmacology
Economic consequences of living kidney donation in Australia: The donor perspective

Research Associate Professor Kevin Pfleger

Centre for Medical Research
Investigation of novel mutations in vasopressin V2 receptor linked with kidney disorders

Research Assistant Professor Shelley Stone

Centre for Clinical Research in Emergency Medicine
Molecular mechanisms of human anaphylaxis: Role of Interleukin-10

Dr Anita Chua

School of Medicine and Pharmacology
The effects of haem on the development of colorectal cancer

Dr Shelley Gorman

Telethon Institute for Child Health Research
The effects of vitamin D deficiency in utero and early childhood on asthma severity

Dr Tak S Cheng

Centre for Orthopaedic Research
TNF-like core domain of RANKL is critical for therapeutic target of osteoporosis

Dr Andrew Wilson

School of Paediatrics and Child Health
Preterm birth, postnatal lung disease and lung structure and function in childhood



Associate Professor Jeffrey Keelan

School of Women’s and Infants’ Health
The ABCs of placental cell death and differentiation

Dr Michaela Lucas

Department of Gastroenterology
Centre for Clinical Immunology and Biomedical Sciences, Royal Perth Hospital
HCV-specific T-cell responses against multiple genotypes associated with viral clearance

Dr Megan Lloyd

School of Biomedical, Biomolecular and Chemical Sciences

A mouse model for congenital human cytomegalovirus infection

Dr Jennifer Rodger

School of Animal Biology
Neural connectivity in the developing and adult brain

Dr Siobhán Reid

School of Sport Science, Exercise and Health
Botulinum toxin-A use in children with cerebral palsy:  Long-term neuromuscular implications



Dr Jason Kirkness

Anatomy and Human Biology
Dynamic modulation of airflow and upper airway properties during polysomnography

Dr Gavin Pinniger

Biomedical, Biomolecular and Chemical Sciences
Functional analysis of anti-inflammatory treatment in dystrophic skeletal muscle that over-express insulin-like growth factor-1 (IGF-1)

Dr Marie Escourt

Centre for Ophthalmology and Visual Science
Immunological requirements for improved viral vaccine design

Dr Esther Ooi

Medicine and Pharmacology
A systems biology approach to study the coordinated regulation and function of apolipoprotein C-III in the metabolic syndrome

Dr Kristen Nowak

Centre for Medical Research
Screening FDA approved drugs for possible treatment of skeletal muscle actin diseases

Dr Peter Dallas

Telethon Institute for Child Heatlh Research
The characterisation of deregulated microRNA expression in paediatric brain tumours

Dr Graeme Polglase

Women’s and Infants’ Heatlh
The effects of antenatal inflammation on cardiopulmonary haemodynamics in preterm lambs

Associate Professor Daniel Fatovich

Primary, Aboriginal and Rural Health Care
A study of trauma patients transferred from rural and remote Western Australia

Dr Alice Vrielink

Biomedical, Biomolecular and Chemical Sciences
Structural studies of the Transcription Elongation Factor Complex Spt4-Spt5

Dr Brian Power

Psychiatry and Clinical Neurosciences
The frequency, mechanism and predictive value of apathy after stroke



Dr Robert McLaughlin

Electrical, Electronic and Computer Engineering
Bringing Optical Imaging into clinical practice for breast cancer and breathing disorders

Dr Robbert van der Most

Medicine & Pharmacology
Using the CD28/B7 family to boost anti-cancer immune responses by blocking antibodies or adenovirus immuno-gene therapy

Dr Anthony Kicic

Paediatrics and Child Health
The role of stem cells in the repair of the airway epithelium

Dr Daniel Chambers

Medicine & Pharmacology
Adult outcomes of bronchopulmonary dysplasia

Dr Sarra Jamieson

Paediatrics and Child Health
The genetics of Otitis Media in Western Australian Children

Dr Peter Noble

Biomedical, Biomolecular and Chemical Sciences
Airway adaptation to Chronic Mechanical Strain

Dr Adrian Keating

Electrical, Electronic and Computer Engineering
Rapid analysis of small volumes of human breast milk using microfluidic technologies

Dr Michael Weinborn

Prospective memory impairment in substance abuse and its relationship to treatment outcome



Dr Paul Besant

Biomedical, Biomolecular and Chemical Sciences
Targeted functional proteomics: Identifying histone H4 histidine kinases in liver cancer

Dr Sharan Dogra

Medicine & Pharmacology
Effect of Rosiglitazone on vascular function in patients with advanced Chronic Kidney Disease

Dr Kate Hammer

Biomedical, Biomolecular and Chemical Sciences
Innate and induced tolerance to Melaleuca alternifolia (tea tree) oil in Gram-positive bacteria

Dr Belinda Knight

Medicine & Pharmacology
The role of PPARg signalling in liver injury, fibrosis and carcinogenesis

Dr Anna Nowak

Medicine & Pharmacology
Chemo-immunotherapy: characterising and exploiting the immune response

Dr Nathan Pavlos

Surgery and Pathology
Tctex-1 regulates Rab3D-mediated vesicle transport during bone resorption

Dr Craig Pennell

Women’s and Infants’ Health
Identifying genetic markers of periodontal disease-associated pre-term birth



Dr Dan Andrews

Centre for Ophthalmology and Visual Science
Antiviral T cell responses: How are they elicited, do they differ with age and are they driven by the virus of the host

Dr Lee Smith

Molecular evolution of murine cytomegalovirus, a model of human pathogen evolution

Dr Sergey Alexandrov

Electrical, Electronic and Computer Engineering
Fourier holographic optical scatter imaging for diagnosis of early-stage cancers

Dr Jane Pillow

Women’s and Infants’ Health
Laying the foundations for a clinical lung function service in newborn intensive care

Dr Barby Singer

Centre for Musculoskeletal Studies
An RCT examining the role of Dysport as an adjunct to patello-femoral joint pain rehabilitation

Dr Ian Lawrance

Medicine & Pharmacology
Modification of intestinal fibrosis in the SPARC-null mouse

Dr Sean Hood

Psychiatry & Clinical Neurosciences
Tryptophan depletion in patients with SSRI-remitted anxiety disorders

Dr Adrian Charles

The role of Caspase 14 in the placenta



Professor David Ravine

WA Institute of Medical Research
Improved understanding of Rett syndrome: Other mutations, other genes.

Professor Sergio Starkstein

Psychiatry and Clinical Neurosciences
Disruption of awareness in patients with cerebro-vascular lesions

Dr Jacqueline Phillips

Division of Health Sciences (Murdoch)
Central control of the circulation, nitric oxide and hypertension: How is the spinal cord involved?

Dr Suzanna Temple

Medicine and Pharmacology
Role of HSP70 polymorphisms in the differential production of TNFa after bacterial infection

Dr Bu Yeap

Medicine and Pharmacology
Role of the glitazones, HODE’s and HETE’s as PPAR gamma ligands in macrophage lipid metabolism

Dr Susan Byrne

Factors influencing the persistence of childhood obesity

Dr Ross Graham

Medicine and Pharmacology
Defining the role of transferrin receptor 2: Effect of mutations on iron homeostasis

Dr Jason White

Anatomy and Human Biology
The role of Pax7 in myogenesis and stem recruitment to the myogenic lineage



Professor Karen Simmer

Womens and Infants Health
Development and use of a fortifier from mother’s milk to supplement breast milk
expressed for pre-term infants

Dr David Burgner

Paediatrics and Child Health
Genetic and epidemiological determinants of susceptibility and outcome in Kawasaki disease

Dr Rachel Skinner

Paediatrics and Child Health
A prospective study to determine the efficacy and acceptability of etonogestrel contraceptive implants(Implanon) in adolescent post-natal population

Dr Bryan Ward

WA Institute for Medical Research
The Carboxy-terminal Tail as a signalling module for the Calcium-sensing Receptor

Dr Deborah Sloboda

Womens and Infants Health
Fetal pancreatic development, prenatal glucocorticoids and the programming of Type 2 Diabetes.

Dr Carolyn King

Animal Biology
The regulation of map-making molecules in the goldfish brain

Professor Leonard Arnolda

Medicine and Pharmacology
Spinal sympathetic tone: the role of synaptic plasticity nirtic oxide and cGMP

Dr Brendan McQuillan

Medicine and Pharmacology
Transcriptional profile of human vascular tissues in patients with atherosclerotic disease



Professor M D Atlas

Tele-otology as a screening and diagnostic tool for ear disease in Aboriginal children

Associate Professor C M Saunders

Gestational breast cancer project

Dr A McKendrick

Vision after migraine: Time course and localisation of deficits

Dr G W Waterer

The influence of cytokine gene polymorphisms on community-acquired pneumonia

Dr J R Burnett

Lipoprotein metabolism and defects of the apolipoprotein B gene: Molecular and metabolic studies in familial hypobetalipoproteinaemia

Dr K A Sanders

Anatomy and Human Biology
The influence of psychosocial facto rs on the success of assisted reproductive technology



Dr A M Thomson

Control of androgen receptor expression in prostate cancer

Dr J K Foster

Investigating the neural mediation of long term memory using Magnetic Resonance Imaging

Dr S E Mutsaers

Regulation of malignant tumour growth by inhibition of extracellular matrix production

Dr T Koppi

The influence of inflammatory derived proteases on dendritic cell biology

Dr J A Wilce

Structure/activity studies of novel toxins from native venomous organisms

Professor D M Greenberg

Psychiatry & Behavioural Science
Cyclical changes associated with violence and suicide in the mentally ill and non-mentally ill



Associate Professor O P Almeida

Psychiatry & Behavioural Science
Effects of testosterone on mood and cognition: Impact of androgen deprivation therapy in patients with prostate cancer and testosterone replacement therapy in hypogonadal patients with Alzheimer’s disease

Dr A Bakker

The effects of the calmodulin, an intracellular signalling molecule activated by Ca2+, on the force responses and sarcoplasmic reticulum function in skinned skeletal muscle fibres

Dr M A Kedda

The pharmacogenetics of the leukotriene pathway in asthma

Dr J M Daly

Novel mRNA-binding proteins involved in inhibition of cancer cell growth

Dr D J Nelson

Immune recognition of multiple tumour antigens

Dr J W Upham

Effects of dust mite allergens on antigen presenting cells from blood and lung



Dr B Iacopetta

DNA methylation, microsatellite instability and the response of cancers to adjuvant therapies

Dr I J Martins

Metabolism of postprandial lipoproteins in obesity and diabetes as assessed by a   13CO2 breath test

Dr J M Bentel

Department of Pathology, Royal Perth Hospital
Control of prostate cancer growth

Dr C F E Platell

The influence of enteral nutrition on peritoneal defence mechanisms

Dr S L Prescott

TVW Institute for Child Health Research
Maternal dietary fatty acids: Role in neonatal immune responses and  the  protection  from atopic disease

Professor A Janca

Psychiatry & Behavioural Science
Genetic epidemiology of personality traits and vulnerability factors in mental disorders